The Löwel lab is focussed on understanding the development and plasticity of neuronal circuits in the mammalian cortex. We use a combination of techniques, including optical imaging, physiology, neuroanatomy and modelling to explore how experience and learning influence the structure and function of nerve cell networks and how activity patterns and genetic factors influence these processes. We hope that answering these key questions not only helps to understand the rules underlying brain development, functioning and learning but additionally will open up new avenues to develop clinically relevant concepts to promote regeneration and rehabilitation for diseased and injured brains.